Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 319 (5871), 1787-9

The Eukaryotic Genome as an RNA Machine

Affiliations

The Eukaryotic Genome as an RNA Machine

Paulo P Amaral et al. Science.

Abstract

The past few years have revealed that the genomes of all studied eukaryotes are almost entirely transcribed, generating an enormous number of non-protein-coding RNAs (ncRNAs). In parallel, it is increasingly evident that many of these RNAs have regulatory functions. Here, we highlight recent advances that illustrate the diversity of ncRNA control of genome dynamics, cell biology, and developmental programming.

Similar articles

  • Noncoding RNA Transcripts
    M Szymański et al. J Appl Genet 44 (1), 1-19. PMID 12590177. - Review
    Recent analyses of the human genome and available data about the other higher eukaryotic genomes have revealed that, in contrast to Eubacteria and Archaea, only a small f …
  • Non-coding RNAs: New Players in Eukaryotic Biology
    FF Costa. Gene 357 (2), 83-94. PMID 16111837. - Review
    The completion of the human, mouse and other eukaryotic genomes were important scientific milestones, but they were just small steps towards the understanding of eukaryot …
  • Long Intronic Noncoding RNA Transcription: Expression Noise or Expression Choice?
    R Louro et al. Genomics 93 (4), 291-8. PMID 19071207. - Review
    Recently, it was discovered that non-protein-coding RNAs (ncRNAs) represent the majority of the human transcripts. Regulatory role of many classes of ncRNAs is broadly re …
  • The Long and the Short of Noncoding RNAs
    CA Brosnan et al. Curr Opin Cell Biol 21 (3), 416-25. PMID 19447594. - Review
    Controlling protein-coding gene expression can no longer be attributed purely to proteins involved in transcription, RNA processing, and translation. The role that noncod …
  • Noncoding but Nonexpendable: Transcriptional Regulation by Large Noncoding RNA in Eukaryotes
    O Yazgan et al. Biochem Cell Biol 85 (4), 484-96. PMID 17713583. - Review
    Genome sequencing and annotation has advanced our understanding of genome organization and gene structure but initially only allowed predictions of how many genes might b …
See all similar articles

Cited by 244 PubMed Central articles

See all "Cited by" articles

Publication types

Substances

LinkOut - more resources

Feedback