Stem cells and the rate of living

Cell Stem Cell. 2007 Jun 7;1(1):9-11. doi: 10.1016/j.stem.2007.05.004.


The "rate-of-living theory" is an ancient explanation of longevity which holds that aging occurs due to the exhaustion of some finite substance-breaths, heartbeats, etc. While this theory as originally conceived has been debunked, new work (Ruzankina et al. [2007], in this issue of Cell Stem Cell) suggests that mammals in fact do have a finite number of stem cell replications per life.

Publication types

  • Comment

MeSH terms

  • Cell Division*
  • Cellular Senescence
  • Humans
  • Stem Cells / cytology*