Does N-cadherin regulate interaction of hematopoietic stem cells with their niches?

Cell Stem Cell. 2007 Aug 16;1(2):127-9. doi: 10.1016/j.stem.2007.07.012.

Abstract

In this issue of Cell Stem Cell, Kiel et al. (2007) demonstrate that N-cadherin is not expressed on repopulating hematopoietic stem cells (HSCs) and that reduction of osteoblasts does not affect HSC frequency, suggesting that other molecular pathways may also modulate the interaction of HSCs with their niches.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cadherins / biosynthesis
  • Cadherins / genetics
  • Cadherins / physiology*
  • Cell Adhesion / physiology
  • Hematopoietic Stem Cells / cytology
  • Hematopoietic Stem Cells / physiology*
  • Mice
  • Osteoblasts / physiology

Substances

  • Cadherins