Knocking the Wnt out of the sails of leukemia stem cell development

Cell Stem Cell. 2007 Dec 13;1(6):597-8. doi: 10.1016/j.stem.2007.11.006.

Abstract

Tumor propagation by cancer stem cells (CSCs) requires their ability to self-renew, and yet the signal pathways involved in this process remain poorly defined. In the December issue of Cancer Cell, Zhao et al. (2007) provide compelling evidence that Wnt/beta-catenin signaling is crucial for the maintenance of chronic myelogenous leukemia (CML) stem cells.

Publication types

  • Review

MeSH terms

  • Disease Progression
  • Gene Deletion
  • Humans
  • Leukemia* / genetics
  • Leukemia* / prevention & control
  • Leukemia* / therapy
  • Signal Transduction / genetics
  • Stem Cells / physiology*
  • Wnt Proteins / genetics*
  • Wnt Proteins / physiology*
  • beta Catenin / physiology*

Substances

  • Wnt Proteins
  • beta Catenin