Niche regulation of muscle satellite cell self-renewal and differentiation

Cell Stem Cell. 2008 Jan 10;2(1):22-31. doi: 10.1016/j.stem.2007.12.012.


Muscle satellite cells have been shown to be a heterogeneous population of committed myogenic progenitors and noncommitted stem cells. This hierarchical composition of differentiating progenitors and self-renewable stem cells assures the extraordinary regenerative capacity of skeletal muscles. Recent studies have revealed a role for asymmetric division in satellite cell maintenance and offer novel insights into the regulation of satellite cell function by the niche. A thorough understanding of the molecular regulation and cell fate determination of satellite cells and other potential stem cells resident in muscle is essential for successful stem cell-based therapies to treat muscular diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Communication
  • Cell Cycle Proteins / physiology
  • Cell Differentiation*
  • Gene Expression Regulation
  • Humans
  • Mice
  • Muscle, Skeletal / physiology*
  • Muscular Dystrophies / therapy
  • Myogenic Regulatory Factor 5 / physiology
  • PAX7 Transcription Factor / physiology
  • Regeneration
  • Satellite Cells, Skeletal Muscle / cytology
  • Satellite Cells, Skeletal Muscle / physiology*
  • Signal Transduction
  • Stem Cell Niche / cytology
  • Stem Cell Niche / physiology*
  • Stem Cell Transplantation


  • Cell Cycle Proteins
  • Myogenic Regulatory Factor 5
  • PAX7 Transcription Factor