A new role for an old friend: NFAT and stem cell quiescence

Cell Stem Cell. 2008 Feb 7;2(2):104-6. doi: 10.1016/j.stem.2008.01.008.

Abstract

NFAT proteins are calcium-regulated transcription factors that play a critical role during the timing and activation of many vertebrate tissues. A recent paper in Cell (Horsley et al., 2008) demonstrates a role of the calcineurin-NFAT-CDK4 pathway in maintaining hair follicle stem cell quiescence.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcineurin / metabolism
  • Hair Follicle / cytology
  • Hair Follicle / physiology*
  • Humans
  • Mice
  • NFATC Transcription Factors / physiology*
  • Signal Transduction / physiology*
  • Stem Cells / physiology*

Substances

  • NFATC Transcription Factors
  • Calcineurin