Foxa2: the rise and fall of dopamine neurons

Cell Stem Cell. 2008 Feb 7;2(2):110-2. doi: 10.1016/j.stem.2008.01.012.


Understanding the development and maintenance of dopamine neurons is essential to establish novel stem cell therapies and animal models of Parkinson's disease. A recent PLoS Biology report (Kittappa et al., 2007) reveals that Foxa2 regulates dopamine neuron generation and differentiation, and that aging foxa2(+/-) mice spontaneously develop Parkinsonism.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Dopamine / metabolism*
  • Hepatocyte Nuclear Factor 3-beta / genetics*
  • Hepatocyte Nuclear Factor 3-beta / metabolism*
  • Humans
  • Mice
  • Mice, Knockout
  • Neurons / metabolism*
  • Neurons / pathology
  • Parkinsonian Disorders / genetics*


  • FOXA2 protein, human
  • Hepatocyte Nuclear Factor 3-beta
  • Dopamine