Antiplatelet drug nonresponsiveness

Am Heart J. 2008 Apr;155(4):591-9. doi: 10.1016/j.ahj.2007.12.034.


The response to most medication, including antiplatelet drugs, is highly variable between individuals. Observational studies have shown that nonresponders to antiplatelet agents appear to have an increased incidence of vascular events. This review article reviews the background, mechanisms, and evidence in support of the clinical significance of this phenomenon.

Publication types

  • Review

MeSH terms

  • Acute Coronary Syndrome / drug therapy*
  • Aspirin / therapeutic use
  • Clopidogrel
  • Coronary Disease / drug therapy
  • Drug Resistance*
  • Humans
  • Platelet Aggregation Inhibitors / pharmacokinetics
  • Platelet Aggregation Inhibitors / pharmacology
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Platelet Function Tests
  • Ticlopidine / analogs & derivatives
  • Ticlopidine / therapeutic use


  • Platelet Aggregation Inhibitors
  • Clopidogrel
  • Ticlopidine
  • Aspirin