Superficial bladder cancer metastatic to the lungs: two case reports and review of the literature

Urology. 2009 Jan;73(1):210.e3-5. doi: 10.1016/j.urology.2008.01.050. Epub 2008 Apr 18.


Bladder cancer remains a significant cause of morbidity and mortality in the United States, with mortality related predominantly to metastasis. Approximately 70% of newly diagnosed cases of bladder cancer represent superficial disease that, despite a high risk of local recurrence, rarely progress to invasive or metastatic disease. The present cases demonstrate isolated pulmonary metastases associated with low-grade superficial bladder cancer, without previous evidence of muscle-invasive disease. Distant spread of low-grade superficial tumors is extremely unusual, and we review the literature and discuss the management of this rare entity.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Carcinoma, Transitional Cell / secondary*
  • Humans
  • Lung Neoplasms / secondary*
  • Male
  • Middle Aged
  • Urinary Bladder Neoplasms / pathology*