Abstract
A new mouse mutation, Sprawling, highlights an essential role for the dynein heavy chain in sensory neuron function, but it lacks the ability of other known heavy-chain mutations to ameliorate neurodegeneration due to defective superoxide dismutase.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amyotrophic Lateral Sclerosis / genetics
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Animals
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Cytoplasm / enzymology
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Cytoplasmic Dyneins
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Dyneins / genetics*
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Dyneins / metabolism
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Humans
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Mice
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Mice, Knockout
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Mutation
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Neurodegenerative Diseases / genetics*
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Neurons, Afferent / physiology
Substances
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Dync1h1 protein, mouse
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Cytoplasmic Dyneins
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Dyneins