Cervical chondroid chordoma in a Shetland sheep dog

J Comp Pathol. 2008 May;138(4):218-23. doi: 10.1016/j.jcpa.2007.12.004.

Abstract

A spayed female Shetland sheep dog aged 12 years was presented for examination with ataxia and hindlimb paralysis. Extradural spinal cord compression was found at the level of vertebrae C6-C7 by radiography and myelocomputed tomography. A jelly-like mass (0.6 x 1.3 cm) was removed surgically. Histopathological findings were characterized by proliferation of vacuolated polygonal cells (physaliphorous cells) in a mucinous matrix and the presence of chondroid tissue shown immunohistochemically to express S-100. The physaliphorous cells were immunolabelled strongly for vimentin and S-100, and weakly for cytokeratin. A diagnosis of canine cervical chondroid chordoma was made. This is considered to be the first report of a chondroid chordoma originating from the cervical region of the spine in the dog.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Biomarkers, Tumor / analysis
  • Cervical Vertebrae / pathology*
  • Chordoma / pathology
  • Chordoma / surgery
  • Chordoma / veterinary*
  • Dog Diseases / pathology*
  • Dog Diseases / surgery
  • Dogs
  • Fatal Outcome
  • Female
  • Myelography / veterinary
  • Periodic Acid-Schiff Reaction / veterinary
  • Spinal Cord Compression / diagnosis
  • Spinal Cord Compression / etiology
  • Spinal Cord Compression / veterinary*
  • Spinal Neoplasms / pathology
  • Spinal Neoplasms / surgery
  • Spinal Neoplasms / veterinary*

Substances

  • Biomarkers, Tumor