Antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. in sucrose-fed rats

J Ethnopharmacol. 2008 May 8;117(2):325-31. doi: 10.1016/j.jep.2008.02.002. Epub 2008 Feb 12.

Abstract

The study was designed to investigate the antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. (TFH-SR) and its underlying mechanism in chronic sucrose-fed rats by evaluating its ability to regulate insulin and angiotensin || levels. Feeding of high-sucrose diet (HS: 77% of kcal from carbohydrate, 16% from protein and 6% from lipid, respectively) for 6 weeks resulted in significant rise in systolic blood pressure (SBP) by 25.60%, plasma insulin by 114.24%, triglycerides by 85.14% and activated angiotensin || contents in heart and kidney. However, TFH-SR treatment significantly suppressed the elevated hypertension, hyperinsulinemia and dyslipidemia. Furthermore, TFH-SR (especially at the dose of 150mg/kg/day) increased the circulatory blood angiotensin || level as effective as angiotensin || receptor blocker. These results indicated that TFH-SR exerted its antihypertensive effects at least in part by improving insulin sensitivity and blocking angiotensin || signal pathway. Findings of the present study suggested that TFH-SR might prove to be of potential use in the management of hyperinsulinemia in non-diabetic state with cardiovascular diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensins / blood
  • Angiotensins / metabolism
  • Animals
  • Antihypertensive Agents / pharmacology*
  • Blood Glucose / metabolism
  • Blood Pressure / drug effects
  • Body Weight / drug effects
  • Diet
  • Elaeagnaceae / chemistry*
  • Flavones / pharmacology*
  • Hyperinsulinism / drug therapy
  • Insulin / blood
  • Insulin / metabolism
  • Insulin Resistance / physiology
  • Kidney / metabolism
  • Myocardium / metabolism
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Seeds / chemistry
  • Sucrose / pharmacology*
  • Triglycerides / blood

Substances

  • Angiotensins
  • Antihypertensive Agents
  • Blood Glucose
  • Flavones
  • Insulin
  • Plant Extracts
  • Triglycerides
  • Sucrose