Urinary uromodulin carries an intact ZP domain generated by a conserved C-terminal proteolytic cleavage

Biochem Biophys Res Commun. 2008 Jun 6;370(3):410-3. doi: 10.1016/j.bbrc.2008.03.099. Epub 2008 Mar 28.


Uromodulin (or Tamm-Horsfall protein) is the most abundant protein in human urine under physiological conditions. Little is known about the molecular mechanism of uromodulin secretion. By extensive Mass Spectrometry analyses we mapped the C-termini of human and murine urinary proteins demonstrating that urinary uromodulin is generated by a conserved C-terminal proteolytic cleavage and retains its entire ZP domain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Conserved Sequence
  • Humans
  • Male
  • Mice
  • Molecular Sequence Data
  • Mucoproteins / chemistry*
  • Mucoproteins / metabolism
  • Mucoproteins / urine*
  • Protein Structure, Tertiary
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Uromodulin


  • Mucoproteins
  • UMOD protein, human
  • Umod protein, mouse
  • Uromodulin