Sodium chloride affects Helicobacter pylori growth and gene expression

J Bacteriol. 2008 Jun;190(11):4100-5. doi: 10.1128/JB.01728-07. Epub 2008 Mar 28.


Epidemiological evidence links high-salt diets and Helicobacter pylori infection with increased risk of developing gastric maladies. The mechanism by which elevated sodium chloride content causes these manifestations is unclear. Here we characterize the response of H. pylori to temporal changes in sodium chloride concentration and show that growth, cell morphology, survival, and virulence factor expression are all altered by increased salt concentration.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Dose-Response Relationship, Drug
  • Gene Expression Regulation, Bacterial / drug effects*
  • Helicobacter pylori / drug effects*
  • Helicobacter pylori / genetics
  • Helicobacter pylori / growth & development*
  • Helicobacter pylori / metabolism
  • Sodium Chloride / pharmacology*
  • Species Specificity
  • Time Factors
  • Virulence Factors / genetics
  • Virulence Factors / metabolism


  • Bacterial Proteins
  • Virulence Factors
  • Sodium Chloride