Wound healing activity of Persea americana (avocado) fruit: a preclinical study on rats

J Wound Care. 2008 Mar;17(3):123-6. doi: 10.12968/jowc.2008.17.3.28670.


Objective: Avocado (Persea americana) oil is rich in nutrient waxes, proteins and minerals, as well as vitamins A, D and E. It is an excellent source of enrichment for dry, damaged or chapped skin. This study aimed to evaluate the wound-healing activity of fruit extract of Persea americana in rats.

Method: The effect of topical and oral administration of Persea americana fruit extract (300 mg/kg/day) on excision and dead space wound models was evaluated. The rats used in the excision wound model were divided into four groups of five each and received either topical or oral treatment. The rats used in the dead space wound model were divided into two groups of five each and were treated orally. Healing was assessed by the rate of wound contraction, period of epithelialisation, granulation tissue weight and hydoxyproline content.

Results: In the excision wound model, complete healing (full epithelialisation) was observed on average on day 14 in the rats who receive oral or topical treatment. In contrast, the controls took approximately 17 days to heal completely. The extract-treated wounds were found to epithelialise faster than the controls (p < 0.001). Wet and dry granulation tissue weight and the hydroxyproline content of the tissue obtained from extract-treated animals used in the dead space wound model were significantly higher (p < 0.05) compared with the controls.

Conclusion: Rate of wound contraction, epithelialisation time together with the hydroxyproline content and histological observations support the use of Persea americana in the management of wound healing.

MeSH terms

  • Administration, Cutaneous
  • Administration, Oral
  • Analysis of Variance
  • Animals
  • Disease Models, Animal*
  • Drug Evaluation
  • Fruit*
  • Granulation Tissue / drug effects
  • Granulation Tissue / ultrastructure
  • Hydroxyproline / analysis
  • Hydroxyproline / drug effects
  • Male
  • Ointments
  • Persea*
  • Phytotherapy / methods*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Rats
  • Rats, Sprague-Dawley
  • Wound Healing / drug effects*
  • Wounds, Penetrating / drug therapy*
  • Wounds, Penetrating / pathology


  • Ointments
  • Plant Extracts
  • Hydroxyproline