Co-enzyme Q10, riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy

Br J Nutr. 2008 Dec;100(6):1179-82. doi: 10.1017/S0007114508968276.


In the present study, eighty-four breast cancer patients were randomized to receive a daily supplement of 100 mg co-enzyme Q10, 10 mg riboflavin and 50 mg niacin (CoRN), one dosage per d along with 10 mg tamoxifen twice per d. A significant increase in poly(ADP-ribose) polymerase levels and disappearance of RASSF1A DNA methylation patterns were found in patients treated with supplement therapy along with tamoxifen compared to untreated breast cancer patients and tamoxifen alone-treated patients. An increase in DNA repair enzymes and disappearance of DNA methylation patterns attributes to reduction in tumour burden and may suggest good prognosis and efficacy of the treatment.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents, Hormonal / therapeutic use
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / genetics
  • DNA Methylation / drug effects*
  • DNA Repair Enzymes / drug effects*
  • DNA Repair Enzymes / metabolism
  • DNA, Neoplasm / genetics
  • Dietary Supplements*
  • Female
  • Humans
  • Middle Aged
  • Niacin / therapeutic use
  • Poly(ADP-ribose) Polymerases / metabolism
  • Riboflavin / therapeutic use
  • Single-Blind Method
  • Tamoxifen / therapeutic use*
  • Ubiquinone / analogs & derivatives
  • Ubiquinone / therapeutic use


  • Antineoplastic Agents, Hormonal
  • DNA, Neoplasm
  • Tamoxifen
  • Ubiquinone
  • Niacin
  • Poly(ADP-ribose) Polymerases
  • DNA Repair Enzymes
  • coenzyme Q10
  • Riboflavin