What to do with an abnormal PSA test

Oncologist. 2008 Mar;13(3):299-305. doi: 10.1634/theoncologist.2007-0139.


For more than a decade, prostate-specific antigen (PSA) has been used for prostate cancer screening. Over the years, this screening has been continually refined, including investigation into the use of lower total PSA thresholds, PSA isoforms, and PSA kinetics. This review describes the evolution of prostate cancer screening and provides clinical insights into the informed use of PSA and its adjunctive measurements.

Publication types

  • Review

MeSH terms

  • Algorithms
  • Decision Making
  • Humans
  • Male
  • Mass Screening*
  • Prognosis
  • Prostate-Specific Antigen / blood*
  • Prostatic Neoplasms / diagnosis*
  • Prostatic Neoplasms / immunology
  • Prostatic Neoplasms / physiopathology
  • Risk Factors


  • Prostate-Specific Antigen