Bilateral anterior uveitis associated with clomiphene citrate

Ocul Immunol Inflamm. 2008 Jan-Feb;16(1):23-4. doi: 10.1080/09273940701799155.


Purpose: To report a case of bilateral anterior uveitis associated with ovulation induction therapy using clomiphene citrate.

Design: Retrospective case review.

Methods: A single patient who developed uveitis while taking clomiphene citrate is described.

Results: A 30-year-old woman with polycystic ovary syndrome developed bilateral anterior uveitis during ovulation induction therapy. Results of laboratory studies were normal and the patient was treated with topical therapy. Upon rechallenge with clomiphene 3 months later, she again developed bilateral anterior uveitis.

Conclusions: Ovulation induction therapy with clomiphene citrate may precipitate uveitis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anovulation / drug therapy
  • Anovulation / etiology
  • Clomiphene / adverse effects*
  • Female
  • Fertility Agents, Female / adverse effects*
  • Humans
  • Ovulation Induction / methods
  • Polycystic Ovary Syndrome / complications
  • Retrospective Studies
  • Uveitis, Anterior / chemically induced*


  • Fertility Agents, Female
  • Clomiphene