The RNA coregulator SRA, its binding proteins and nuclear receptor signaling activity

IUBMB Life. 2008 Mar;60(3):159-64. doi: 10.1002/iub.22.


Nuclear receptor (NR) coregulators are key modulators of hormone signaling. Discovery of steroid receptor RNA activator (SRA), a coregulator that is active as a RNA, transformed thinking in the field of hormone action. The subsequent identification of SRA-binding coregulator proteins, including p68, SHARP and more recently SLIRP, has provided important insight into SRA's mechanism of action and potentially offers new opportunities to target NR signaling pathways for therapeutic gain. Here we outline advances in the field of NR coregulator biology, with a bias on recent progress in understanding SRA-protein interactions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins
  • Homeodomain Proteins / metabolism
  • Humans
  • Mitochondria / metabolism
  • MyoD Protein / metabolism
  • Nuclear Proteins / metabolism
  • RNA / metabolism*
  • RNA, Long Noncoding
  • RNA, Untranslated / genetics
  • RNA, Untranslated / metabolism*
  • RNA-Binding Proteins / metabolism
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Signal Transduction / physiology*
  • Tumor Suppressor Protein p53 / metabolism


  • DNA-Binding Proteins
  • Homeodomain Proteins
  • MyoD Protein
  • MyoD1 myogenic differentiation protein
  • Nuclear Proteins
  • RNA, Long Noncoding
  • RNA, Untranslated
  • RNA-Binding Proteins
  • Receptors, Cytoplasmic and Nuclear
  • SLIRP protein, human
  • SPEN protein, human
  • TP53 protein, human
  • Tumor Suppressor Protein p53
  • steroid receptor RNA activator
  • RNA