Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

Genes Dev. 2008 Apr 1;22(7):832-53. doi: 10.1101/gad.1652708.


Over the past few years it has become evident that the intermediate filament proteins, the types A and B nuclear lamins, not only provide a structural framework for the nucleus, but are also essential for many aspects of normal nuclear function. Insights into lamin-related functions have been derived from studies of the remarkably large number of disease-causing mutations in the human lamin A gene. This review provides an up-to-date overview of the functions of nuclear lamins, emphasizing their roles in epigenetics, chromatin organization, DNA replication, transcription, and DNA repair. In addition, we discuss recent evidence supporting the importance of lamins in viral infections.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Nucleus / metabolism*
  • Cell Nucleus / ultrastructure
  • Chromatin / metabolism*
  • Humans
  • Lamins / genetics
  • Lamins / physiology*
  • Microscopy, Electron
  • Mutation
  • Nuclear Proteins / genetics
  • Nuclear Proteins / physiology*
  • Progeria / genetics


  • Chromatin
  • Lamins
  • Nuclear Proteins