Progress in dendritic cell immunotherapy: elucidating the enigma of Th-1 polarization

Hum Vaccin. Mar-Apr 2008;4(2):162-4. doi: 10.4161/hv.4.2.5091. Epub 2007 Sep 26.

Abstract

The goal of harnessing the immune system to effectively eradicate neoplastic disease will require the generation of robust Th-1 type immunity and durable immunological memory against the antigenic repertoire that differentiates normal self from neoplastic self. While the literature presents a very mixed picture as to the requirement of T-cell help for the generation of both primary and memory CTL responses, there appears to be a general consensus that CD4(+) T-cell help will be required to generate durable responses against self cancer antigens that are devoid of foreign PAMPs and for which high-affinity T-cell clones have been deleted as a consequence of thymic selection. Here we comment briefly upon the characterization of an emerging regulatory pathway that enhances Th-1 polarization and CD8(+) CTL responses by a mechanism dependent upon CD40L-mediated T-cell help. Further, we speculate that the full elucidation of this mechanism might be generally useful in answering some unresolved questions regarding the initiation of Th-1 polarized responses.

MeSH terms

  • Animals
  • CD40 Ligand
  • Cell Polarity / immunology*
  • Dendritic Cells / immunology*
  • Humans
  • Immunotherapy
  • T-Lymphocytes, Cytotoxic / immunology
  • Th1 Cells / immunology
  • Th1 Cells / physiology*
  • Vaccination

Substances

  • CD40 Ligand