Rejuvenating influence of a stabilized hyaluronic acid-based gel of nonanimal origin on facial skin aging

Dermatol Surg. 2008 May;34(5):720-6. doi: 10.1111/j.1524-4725.2008.34176.x. Epub 2008 Apr 1.


Background: Skin changes associated with aging, such as loss of elasticity and turgor, can have a negative psychosocial impact. Current treatment options aimed at restoring elasticity are often ineffective or hampered by a poor risk/benefit ratio.

Objective: Clinical observations and biophysical measurements were used to assess the effect of middermal placement of stabilized hyaluronic acid-based gel of nonanimal origin (NASHA, Restylane, Vital, Q-Med) on the appearance and elasticity of facial skin.

Methods and materials: In this pilot study, 19 female patients underwent a series of three treatment sessions, spaced 4 weeks apart, with NASHA injected into the lower cheeks. Elasticity, skin surface roughness, dermal thickness, and density were evaluated at each treatment session and at 4 and 12 weeks after the last treatment session. Patient satisfaction was assessed, and photographs were taken at each visit.

Results: During the course of the study, skin elasticity and surface roughness improved significantly. Patient feedback was extremely positive.

Conclusion: Micropuncture placement of NASHA can exert a rejuvenating effect on facial skin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Elasticity
  • Female
  • Humans
  • Hyaluronic Acid / analogs & derivatives
  • Injections, Intradermal
  • Pilot Projects
  • Prospective Studies
  • Prostheses and Implants
  • Rejuvenation*
  • Skin Aging / drug effects*


  • Hyaluronic Acid
  • Restylane