Hypoxia in microscopic tumors

Cancer Lett. 2008 Jun 18;264(2):172-80. doi: 10.1016/j.canlet.2008.02.037. Epub 2008 Apr 1.


Tumor hypoxia has been commonly observed in a broad spectrum of primary solid malignancies. Hypoxia is associated with tumor progression, increased aggressiveness, enhanced metastatic potential and poor prognosis. Hypoxic tumor cells are resistant to radiotherapy and some forms of chemotherapy. Using an animal model, we recently showed that microscopic tumors less than 1mm diameter were severely hypoxic. In this review, models and techniques for the study of hypoxia in microscopic tumors are discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Hypoxia / physiology*
  • Humans
  • Neoplasm Metastasis / pathology*
  • Neoplasms / pathology*