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Review
, 20 (8), 1415-22

Highlighting the Role of Ras and Rap During Dictyostelium Chemotaxis

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Review

Highlighting the Role of Ras and Rap During Dictyostelium Chemotaxis

Arjan Kortholt et al. Cell Signal.

Abstract

Chemotaxis, the directional movement towards a chemical compound, is an essential property of many cells and has been linked to the development and progression of many diseases. Eukaryotic chemotaxis is a complex process involving gradient sensing, cell polarity, remodelling of the cytoskeleton and signal relay. Recent studies in the model organism Dictyostelium discoideum have shown that chemotaxis does not depend on a single molecular mechanism, but rather depends on several interconnecting pathways. Surprisingly, small G-proteins appear to play essential roles in all these pathways. This review will summarize the role of small G-proteins in Dictyostelium, particularly highlighting the function of the Ras subfamily in chemotaxis.

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