SRC-3 transcription-coupled activation, degradation, and the ubiquitin clock: is there enough coactivator to go around in cells?

Sci Signal. 2008 Apr 1;1(13):pe16. doi: 10.1126/stke.113pe16.

Abstract

Overexpression of nuclear receptor coactivators is a frequent event in breast cancer cells and is recognized as a key mechanism for these cells to maximize their oncogenic growth state. Steroid receptor coactivator-3 [(SRC-3), also known as amplified in breast cancer-1 or AIB1] is foremost among these overexpressed oncogenic coactivators, being overexpressed in most breast cancers. Because of its oncogenic potential, normal cells must carefully control its cellular concentration. We discuss how SRC-3 quantitatively influences estrogen-regulated gene transcription when it is at limiting concentrations in normal breast cells and at nonlimiting concentrations in breast cancer cells. Precise control of the cellular concentration of SRC-3 may thus serve as a mechanism for defining growth responses to estrogen receptors and other growth-promoting transcription factors.

MeSH terms

  • Cell Line, Tumor
  • Histone Acetyltransferases / physiology*
  • Humans
  • Nuclear Receptor Coactivator 3
  • Trans-Activators / physiology*
  • Transcriptional Activation*
  • Ubiquitin / physiology*

Substances

  • Trans-Activators
  • Ubiquitin
  • Histone Acetyltransferases
  • NCOA3 protein, human
  • Nuclear Receptor Coactivator 3