Comparison of C-reactive protein and serum amyloid a protein in septic shock patients

Mediators Inflamm. 2008;2008:631414. doi: 10.1155/2008/631414.


Septic shock is a severe inflammatory state caused by an infectious agent. Our purpose was to investigate serum amyloid A (SAA) protein and C-reactive protein (CRP) as inflammatory markers of septic shock patients. Here we evaluate 29 patients in postoperative period, with septic shock, in a prospective study developed in a surgical intensive care unit. All eligible patients were monitored over a 7-day period by sequential organ failure assessment (SOFA) score, daily CRP, SAA, and lactate measurements. CRP and SAA strongly correlated up to the fifth day of observation but were not good predictors of mortality in septic shock.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • C-Reactive Protein / metabolism*
  • Female
  • Humans
  • Intensive Care Units
  • Male
  • Middle Aged
  • Multiple Organ Failure / blood
  • Multiple Organ Failure / diagnosis
  • Postoperative Care / methods
  • Predictive Value of Tests
  • Prospective Studies
  • Serum Amyloid A Protein / metabolism*
  • Shock, Septic / blood*
  • Shock, Septic / diagnosis
  • Shock, Septic / mortality
  • Survival Rate
  • Time Factors


  • Serum Amyloid A Protein
  • C-Reactive Protein