Primarily non-surgical management of osteomyelitis of the foot in diabetes

Diabetologia. 2008 Jun;51(6):962-7. doi: 10.1007/s00125-008-0976-1. Epub 2008 Apr 3.

Abstract

Aims/hypothesis: We examined the use of surgery and assessed the response to non-surgical management of osteomyelitis of the foot in diabetic patients.

Methods: We reviewed the records of all patients presenting to a single specialist centre with osteomyelitis complicating a diabetic foot ulcer over a 5 year period. Details were extracted on antibiotic choice and treatment duration, hospital admission, incidence of minor and major amputation, and 12 month outcomes.

Results: There were 147 patients, with mean age 64.7 years (66% men). Of these, 26 (18%) were admitted to hospital at the time of presentation and managed with intravenous antibiotics; the remainder were managed with oral antibiotics as outpatients. Surgery was undertaken because of life- or limb-threatening infection, or failure to respond, in 34 (23%) patients (minor amputation 28, major amputation six patients). The remaining 113 were managed non-surgically. Remission was induced in 66 (58.4% of 113), while 35 (31%) had a relapse. Of those experiencing relapse, 27 (77%) achieved apparent arrest of the infection with a further course of antibiotics; six underwent minor and two underwent major amputation. Of all 113 whose infection was initially managed without surgery, apparent remission was achieved with antibiotics alone in 93 (82.3%).

Conclusions/interpretation: As these observations were made in an unselected case series, they give more insight into the respective roles of surgical and non-surgical management. The results confirm that although urgent surgery is indicated in some patients, non-surgical management of those without limb-threatening infection is associated with a high rate of apparent remission.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Amputation
  • Anti-Bacterial Agents / therapeutic use
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 2 / complications
  • Diabetic Foot / drug therapy
  • Diabetic Foot / surgery
  • Diabetic Foot / therapy*
  • Humans
  • Middle Aged
  • Osteomyelitis / drug therapy
  • Osteomyelitis / surgery
  • Osteomyelitis / therapy*
  • Outpatients

Substances

  • Anti-Bacterial Agents