Hemophagocytic syndrome in Dengue hemorrhagic fever with severe multiorgan complications

J Med Assoc Thai. 2008 Jan;91(1):104-9.


A 46 year old woman who presented with severe multiorgans involvement including liver brain, cardio-pulmonary failure, gastrointestinal bleeding, progressive cytopenia, DIC and hemophagocytic syndrome during the convalescent phase of Dengue type II has been successfully treated primarily with pulse methyl prednisolone and high dose intravenous immunoglobulin G. The authors believe that HPCS are not infrequently seen with high mortality and recommended early diagnosis and treatment with the regimen. This is the first complete report of hemophagocytic syndrome in adult dengue hemorrhagic fever in Thailand. The literature of HPCS in DHF was reviewed and discussed.

Publication types

  • Case Reports

MeSH terms

  • Dexamethasone / therapeutic use
  • Female
  • Furosemide / therapeutic use
  • Humans
  • Immunoglobulin G / administration & dosage
  • Immunoglobulin G / therapeutic use
  • Lymphohistiocytosis, Hemophagocytic / diagnosis*
  • Lymphohistiocytosis, Hemophagocytic / etiology
  • Middle Aged
  • Multiple Organ Failure / etiology
  • Risk Factors
  • Severe Dengue / complications*
  • Severe Dengue / physiopathology
  • Thailand


  • Immunoglobulin G
  • Furosemide
  • Dexamethasone