To (TGF)beta or not to (TGF)beta: fine-tuning of Smad signaling via post-translational modifications

Cell Signal. 2008 Sep;20(9):1579-91. doi: 10.1016/j.cellsig.2008.02.003. Epub 2008 Feb 15.


Smad proteins are key signal transducers for the TGF-beta superfamily and are frequently inactivated in human cancers, yet the molecular basis of how their levels and activities are regulated remains unclear. Recent progress, discussed herein, illustrates the critical roles of Smad post-translational modifications in the cellular outcome to TGF-beta signaling.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Amino Acid Motifs
  • Animals
  • Humans
  • Neoplasms / metabolism
  • Protein Processing, Post-Translational*
  • Signal Transduction*
  • Smad Proteins / chemistry
  • Smad Proteins / metabolism*
  • Transforming Growth Factor beta / metabolism*


  • Smad Proteins
  • Transforming Growth Factor beta