Role of CAGE, a novel cancer/testis antigen, in various cellular processes, including tumorigenesis, cytolytic T lymphocyte induction, and cell motility

J Microbiol Biotechnol. 2008 Mar;18(3):600-10.


A cancer-associated antigen gene (CAGE) was identified by serological analysis of a recombinant cDNA expression library (SEREX). The gene was identified by screening cDNA expression libraries of human testis and gastric cancer cell lines with sera from patients with gastric cancer. CAGE was found to contain a D-E-A-D box domain and encodes a putative protein of 630 amino acids with possible helicase activity. The CAGE gene is widely expressed in various cancer tissues and cancer cell lines. Demethylation plays a role in the activation of CAGE in certain cancer cell lines where the gene is not expressed. The functional roles of CAGE in tumorigenesis, the molecular mechanisms of CAGE expression, and cell motility are also discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Neoplasm / chemistry
  • Antigens, Neoplasm / genetics
  • Antigens, Neoplasm / immunology
  • Antigens, Neoplasm / metabolism*
  • Cell Line, Tumor
  • Cell Movement*
  • DEAD-box RNA Helicases / chemistry
  • DEAD-box RNA Helicases / genetics
  • DEAD-box RNA Helicases / immunology
  • DEAD-box RNA Helicases / metabolism*
  • Gene Expression Regulation, Neoplastic
  • Gene Library
  • Humans
  • Male
  • Molecular Sequence Data
  • Stomach Neoplasms / genetics
  • Stomach Neoplasms / metabolism
  • T-Lymphocytes, Cytotoxic / immunology*
  • Testicular Neoplasms / genetics
  • Testicular Neoplasms / metabolism*


  • Antigens, Neoplasm
  • DDX53 protein, human
  • DEAD-box RNA Helicases