Elevated soluble lectin-like oxidized LDL receptor-1 (sLOX-1) levels in obese postmenopausal women

Obesity (Silver Spring). 2008 Jun;16(6):1454-6. doi: 10.1038/oby.2008.213. Epub 2008 Apr 3.


We investigated the association between soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels and obesity in older women. Fifty-one postmenopausal women (10 lean, 22 overweight, and 19 obese) were included in this small retrospective analysis. Plasma sLOX-1 levels were measured using a chemiluminescent enzyme-linked immunoassay. Plasma levels of sLOX-1 were significantly higher in obese women (55.33 +/- 4.49 pg/ml) compared to lean (30.91 +/- 6.19 pg/ml, P = 0.002) and overweight women (38.31 +/- 4.18 pg/ml, P = 0.017). Plasma sLOX-1 levels were positively associated with body weight, BMI, total body fat, and trunk fat. The relationship between sLOX-1 and BMI was attenuated after adjustment for age, hormone replacement therapy, and body fat. In conclusion, obese women have higher sLOX-1 levels, which may reflect increased LOX-1 expression in adipose tissue.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adipose Tissue
  • Adiposity
  • Body Mass Index
  • Body Weight
  • Case-Control Studies
  • Female
  • Humans
  • Middle Aged
  • Obesity / blood*
  • Overweight / blood
  • Postmenopause / blood*
  • Retrospective Studies
  • Scavenger Receptors, Class E / blood*
  • Thinness / blood


  • OLR1 protein, human
  • Scavenger Receptors, Class E