Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years

Nat Med. 2008 May;14(5):507-9. doi: 10.1038/nm1752. Epub 2008 Apr 6.


Postmortem analysis of five subjects with Parkinson's disease 9-14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain Tissue Transplantation / methods
  • Brain Tissue Transplantation / pathology*
  • Fetal Tissue Transplantation / methods
  • Fetal Tissue Transplantation / pathology*
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Neurons / pathology*
  • Parkinson Disease / diagnostic imaging
  • Parkinson Disease / therapy*
  • Positron-Emission Tomography
  • Treatment Outcome
  • Tyrosine 3-Monooxygenase


  • Tyrosine 3-Monooxygenase