Repeated administration of MK-801 produces sensitization to its own locomotor stimulant effects but blocks sensitization to amphetamine

Brain Res. 1991 Oct 18;562(1):164-8. doi: 10.1016/0006-8993(91)91202-c.


Repeated amphetamine administration produced behavioral sensitization to subsequent amphetamine challenge. The development of sensitization was blocked by coadministration of the N-methyl-D-aspartate (NMDA) antagonist MK-801. Conditioned locomotion, as revealed by saline challenge, was also blocked by MK-801, suggesting that behavioral sensitization and conditioned locomotion may share a requirement for NMDA receptor stimulation. Repeated MK-801 administration produced behavioral sensitization to MK-801 but not amphetamine challenge, suggesting that MK-801 itself produces sensitization through a different mechanism than amphetamine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphetamine / administration & dosage
  • Amphetamine / antagonists & inhibitors
  • Amphetamine / pharmacology*
  • Animals
  • Dizocilpine Maleate / administration & dosage
  • Dizocilpine Maleate / pharmacology*
  • Drug Administration Schedule
  • Male
  • Motor Activity / drug effects*
  • Rats
  • Rats, Inbred Strains
  • Receptors, N-Methyl-D-Aspartate / drug effects
  • Receptors, N-Methyl-D-Aspartate / physiology
  • Reference Values


  • Receptors, N-Methyl-D-Aspartate
  • Dizocilpine Maleate
  • Amphetamine