Immunomodulator therapy migration in relapsing remitting multiple sclerosis: a study of 152 cases

Arq Neuropsiquiatr. 2008 Mar;66(1):11-4. doi: 10.1590/s0004-282x2008000100004.


Background: Since 1997, immunological modulators have been used for treatment of Relapsing Remitting Multiple Sclerosis (RRMS) in the Multiple Sclerosis Attendance and Treatment Center (CATEM) with significant alterations in this disease natural history.

Aim: To add data on the experience of CATEM for the treatment of RRMS patients that had immunomodulators.

Method: RRMS patients that received continuously immunomodulator drugs were evaluated on adherence, migration, withdrawal and progression rates. The patients were divided in three groups by the period of immunomodulators intake.

Results: There were registered in Group 1 withdrawal in 98 patients (25%) and adherence in 292 cases (74%); Group 2 interruption of therapy in 140 patients, 92 (31%) due to progression for PSMS, 14 (5%) for pregnancy, withdrawal in 34 (11%), adherence in 88%; Group 3 progression in 41 (26%), pregnancy in 3 (2%) withdrawal in 42 (27%) and adherence in 72%. The migration rate was about one third (31.57%) and the principal cause was therapeutic failure; the mean migrating time was 0.5-2.5 years in group 3.

Conclusion: Immunomodulatory treatment for RRMS patients may have significant levels of failure and side effects; the adherence was compatible with the international literature.

MeSH terms

  • Female
  • Humans
  • Immunologic Factors / adverse effects
  • Immunologic Factors / therapeutic use*
  • Interferon-beta / adverse effects
  • Interferon-beta / therapeutic use*
  • Multiple Sclerosis, Relapsing-Remitting / drug therapy*
  • Patient Compliance / statistics & numerical data
  • Patient Dropouts / statistics & numerical data
  • Retrospective Studies
  • Time Factors
  • Treatment Outcome


  • Immunologic Factors
  • Interferon-beta