Evolution of DNA polymerase iota structure and function in eukaryotes

Biochemistry (Mosc). 2008 Mar;73(3):346-52. doi: 10.1134/s0006297908030176.


Analysis of DNA polymerase iota (Pol iota) enzymic activity in different classes of eukaryotes has shown that error-prone activity of this enzyme can be found only in mammals, and that it is completely absent from organisms that are at lower stages of development. It was supposed that the emergence of the error-prone Pol iota activity in mammals is caused by structural alteration of the active center. Possible functions of error-prone Pol iota in higher eukaryotes are discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry
  • Animals
  • Binding Sites
  • Cell Extracts
  • DNA-Directed DNA Polymerase / chemistry*
  • DNA-Directed DNA Polymerase / genetics
  • DNA-Directed DNA Polymerase / metabolism
  • Dogs
  • Evolution, Molecular*
  • Rabbits
  • Rats


  • Amino Acids
  • Cell Extracts
  • DNA polymerase iota
  • DNA-Directed DNA Polymerase