Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Apr;9(2):67-76.
doi: 10.2174/138920108783955191.

Characterization and Prediction of Protein Interfaces to Infer Protein-Protein Interaction Networks

Affiliations
Review

Characterization and Prediction of Protein Interfaces to Infer Protein-Protein Interaction Networks

Ozlem Keskin et al. Curr Pharm Biotechnol. .

Abstract

Complex protein-protein interaction networks govern biological processes in cells. Protein interfaces are the sites where proteins physically interact. Identification and characterization of protein interfaces will lead to understanding how proteins interact with each other and how they are involved in protein-protein interaction networks. What makes a given interface bind to different proteins; how similar/different the interactions in proteins are some key questions to be answered. Enormous amount of protein structures and experimental protein-protein interactions data necessitate advanced computational methods for analyzing and inferring new knowledge. Interface prediction methods use a wide range of sequence, structural and physico-chemical characteristics that distinguish interface residues from non-interface surface residues. Here, we present a review focusing on the characteristics of interfaces and the current status of interface prediction methods.

Similar articles

See all similar articles

Cited by 10 articles

See all "Cited by" articles

LinkOut - more resources

Feedback