The genetics of cancer survivorship

Hematol Oncol Clin North Am. 2008 Apr;22(2):257-69, vi-vii. doi: 10.1016/j.hoc.2008.01.001.


Constitutional (hereditary) genetic variation and somatic genetic alterations acquired during transformation to the neoplastic phenotype are both critical determinants of cancer outcome, and can ultimately have a significant effect on cancer survivorship. This article discusses the role of constitutional and somatic genetics in determining outcome and survivorship following a diagnosis of cancer using illustrative examples primarily from the hematologic malignancies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chromosome Aberrations / drug effects
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Neoplasms / drug therapy
  • Neoplasms / genetics*
  • Neoplasms / rehabilitation
  • Polymorphism, Single Nucleotide
  • Survivors*