TARC and IL-5 expression correlates with tissue eosinophilia in peripheral T-cell lymphomas

Leuk Res. 2008 Sep;32(9):1431-8. doi: 10.1016/j.leukres.2008.02.016. Epub 2008 Apr 18.


The current study attempts to characterize the eosinophilia associated with T-cell lymphomas and to investigate its possible relationship with the secretion of eosinophil-stimulating factors by lymphoma cells and/or intra-tumoral surrounding cells. Paraffin-embedded specimens from 50 patients diagnosed with peripheral T-cell lymphomas, either unspecified (PTCL-U, n=30) or angioimmunoblastic (AITL, n=20) were morphologically assessed for intra-tumoral eosinophilia and analyzed by immunohistochemistry using specific antibodies directed against TARC, IL-5, RANTES, and eotaxin. The AITL and PTCL-U cases contained a mean of 147+/-41 and 102+/-37 eosinophils per 10 high power fields, respectively. Thirty-two of 47 cases (68%) showed IL-5-positive lymphoma cells while 15/50 (30%) tumors showed variable staining for TARC in scattered non-lymphoid cells with dendritic morphology. TARC and IL-5-positive cases possessed significantly more eosinophils. Our data indicate that IL-5 and TARC expression highly correlate with eosinophilia in T-cell lymphomas, suggesting that these chemokines are involved in the recruitment of eosinophils into the tumors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Chemokine CCL11 / metabolism
  • Chemokine CCL17 / metabolism*
  • Chemokine CCL5 / metabolism
  • Eosinophilia / metabolism*
  • Eosinophilia / pathology
  • Eosinophils / pathology
  • Female
  • Humans
  • Immunoblastic Lymphadenopathy / metabolism
  • Immunoblastic Lymphadenopathy / pathology
  • Immunoenzyme Techniques
  • Interleukin-5 / metabolism*
  • Lymphoma, T-Cell, Peripheral / metabolism*
  • Lymphoma, T-Cell, Peripheral / pathology
  • Male
  • Middle Aged
  • Prognosis


  • CCL11 protein, human
  • CCL17 protein, human
  • Chemokine CCL11
  • Chemokine CCL17
  • Chemokine CCL5
  • IL5 protein, human
  • Interleukin-5