Searching for autoimmunity in "antibiotic-refractory" Lyme arthritis

Mol Immunol. 2008 Jun;45(11):3023-4. doi: 10.1016/j.molimm.2008.02.015. Epub 2008 Apr 18.


In two recent articles published in Molecular Immunology, Steere and colleagues continue their search for an autoimmune mechanism of arthritis in patients who have failed short-course antibiotic therapy for Borrelia burgdorferi, the spirochetal agent of Lyme disease. As in previous attempts, the authors fail to elucidate a molecular mimicry mechanism for the putative autoimmune process, leading to the conclusion that there is no credible scientific evidence for a post-infectious autoimmune mechanism of arthritis in chronic Lyme disease.

Publication types

  • Comment
  • Letter

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Autoimmunity / drug effects
  • Autoimmunity / immunology*
  • Borrelia burgdorferi / drug effects
  • Borrelia burgdorferi / immunology
  • Drug Resistance, Bacterial* / drug effects
  • Humans
  • Lyme Disease / drug therapy*
  • Lyme Disease / immunology*
  • Mice
  • Molecular Mimicry / drug effects


  • Anti-Bacterial Agents