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Randomized Controlled Trial
. 2008 Jul;102(1):44-9.
doi: 10.1016/j.ijgo.2008.01.028. Epub 2008 Apr 8.

Effect of Intestinal Production of Equol on Menopausal Symptoms in Women Treated With Soy Isoflavones

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Randomized Controlled Trial

Effect of Intestinal Production of Equol on Menopausal Symptoms in Women Treated With Soy Isoflavones

Hei-Jen Jou et al. Int J Gynaecol Obstet. .

Abstract

Objective: To evaluate the effect of soy isoflavones on menopausal symptoms in women who do and who do not produce equol, a daidzein metabolite.

Method: A randomized, double-blind, placebo-controlled clinical trial was conducted over 6 months with 96 healthy menopausal women. After taking take 135 mg of isoflavones daily for 1 week, the women in the study group were assigned to the equol-producing (EP) or the non-EP group according to the presence or absence of equol in their urine. Menopausal symptoms were evaluated using a modified Kupperman Index.

Result: Compared with the placebo group, the scores for hot flashes and excessive sweating were significantly reduced after 3 months, and the scores for weakness, palpitations, limb paresthesia, and total symptoms after 6 months, in the EP group only.

Conclusions: Isoflavone supplementation improves menopausal symptoms only in women with the ability to produce equol.

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