Clinical application of regulatory T cells for treatment of type 1 diabetes and transplantation

Eur J Immunol. 2008 Apr;38(4):931-4. doi: 10.1002/eji.200738108.


Immune regulation is a complex process that depends on the maintenance of self tolerance while retaining robust immune responses against microbes. The emergence of Treg as a central mechanism for immune regulation has generated a new paradigm where Treg-resistant memory T cells and/or "defective" Treg lead to a breakdown in tolerance resulting in immune pathology. In this perspective, we highlight the opportunities and challenges in the field of Treg therapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Separation
  • Cells, Cultured
  • Diabetes Mellitus, Type 1 / immunology*
  • Diabetes Mellitus, Type 1 / surgery
  • Diabetes Mellitus, Type 1 / therapy*
  • Humans
  • Islets of Langerhans Transplantation*
  • T-Lymphocytes, Regulatory / cytology
  • T-Lymphocytes, Regulatory / immunology*