The association of peripheral arterial occlusive disease with major coronary events in a mediterranean population with low coronary heart disease incidence

Eur J Vasc Endovasc Surg. 2008 Jul;36(1):71-6. doi: 10.1016/j.ejvs.2008.01.029. Epub 2008 Apr 18.


Objectives: The association of peripheral arterial occlusive disease (PAD) association with major coronary events (MCE) has been well documented, nevertheless data are lacking for populations with a low incidence of coronary heart disease (CHD). We aimed to assess the association of PAD with MCE in a Mediterranean population.

Design: Prospective survey of 699 55-74 year-old men representative of an urban district near Barcelona (Spain).

Methods: Baseline cardiovascular risk factors, CHD and PAD (ankle/brachial index<0.9) were recorded. MCE were evaluated during the 5-year follow-up.

Results: At recruitment 94 subjects (13.4%) had PAD. During follow-up (mean 69.3 months), 35 (5%) subjects suffered a MCE, of whom 12 had PAD, 9 previous symptomatic CHD and 1 subject both conditions. Higher CHD related mortality (8.6% vs 1.4%; p<0.001) and lower MCE-free survival (78.67% vs 93.26%; p<0.001) was observed for PAD subjects. On Cox regression analysis PAD (RR=3; p=0.003) and previous symptomatic CHD (RR=4.1; p<0.001) were associated independently with MCE during follow-up.

Conclusions: Even in a population with a low incidence of CHD there is a strong relationship between PAD and future MCE. Screening for PAD may improve the selection of patients targeted for cardiovascular risk prevention.

MeSH terms

  • Aged
  • Arterial Occlusive Diseases / complications*
  • Arterial Occlusive Diseases / mortality
  • Cardiovascular Diseases / etiology*
  • Cardiovascular Diseases / mortality
  • Cardiovascular Diseases / prevention & control
  • Coronary Disease / complications*
  • Coronary Disease / mortality
  • Coronary Disease / prevention & control
  • Follow-Up Studies
  • Humans
  • Incidence
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Peripheral Vascular Diseases / complications*
  • Peripheral Vascular Diseases / mortality
  • Population Surveillance
  • Prevalence
  • Proportional Hazards Models
  • Risk Assessment
  • Risk Factors
  • Spain / epidemiology
  • Time Factors