The great divide: coordinating cell cycle events during bacterial growth and division

Curr Opin Microbiol. 2008 Apr;11(2):94-9. doi: 10.1016/j.mib.2008.02.008. Epub 2008 Apr 7.


The relationship between events during the bacterial cell cycle has been the subject of frequent debate. While early models proposed a relatively rigid view in which DNA replication was inextricably coupled to attainment of a specific cell mass, and cell division was triggered by the completion of chromosome replication, more recent data suggest these models were oversimplified. Instead, an intricate set of intersecting, and at times opposing, forces coordinate DNA replication, cell division, and cell growth with one another, thereby ensuring the precise spatial and temporal control of cell cycle events.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Bacillus subtilis / cytology
  • Bacillus subtilis / genetics
  • Bacillus subtilis / growth & development*
  • Bacillus subtilis / metabolism
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Cell Cycle
  • Cell Division*
  • Chromosome Segregation
  • DNA Replication
  • Escherichia coli / cytology
  • Escherichia coli / genetics
  • Escherichia coli / growth & development*
  • Escherichia coli / metabolism
  • Gene Expression Regulation, Bacterial


  • Bacterial Proteins