Lamellipodia and filopodia in metastasis and invasion

FEBS Lett. 2008 Jun 18;582(14):2102-11. doi: 10.1016/j.febslet.2008.03.039. Epub 2008 Apr 7.


Advances in our understanding of the mechanisms of lamellipodia and filopodia assembly have led to a better concept of how cells move, including how the actin cytoskeleton might be important for the motility of metastatic cancer cells. The cytoskeleton is a potentially interesting target for prevention of invasion and metastasis. As key proteins are uncovered which regulate the assembly of actin-based structures, these need to be considered in light of whether they represent potential invasion and metastasis proteins.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Movement
  • Cytoskeleton / metabolism*
  • Humans
  • Mice
  • Microfilament Proteins / metabolism*
  • Neoplasm Invasiveness*
  • Neoplasm Metastasis*
  • Pseudopodia / metabolism*


  • Microfilament Proteins