Abstract
An amide linked conjugate of p-aminophenylarsine oxide and biotin is conveniently prepared in a one-pot procedure by the reaction of biotinyl chloride, formed in situ, with p-aminophenyldichloroarsine. The reaction of the arsine oxide-biotin conjugate with 1,2-ethanedithiol produces the stabilized dithiarsolane. These reagents are now readily available for a variety of applications.
Publication types
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Research Support, N.I.H., Intramural
MeSH terms
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Arsenicals / chemical synthesis*
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Arsenicals / chemistry*
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Biotin / chemistry*
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Mercaptoethanol / analogs & derivatives
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Mercaptoethanol / chemistry
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Molecular Structure
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Stereoisomerism
Substances
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Arsenicals
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N-(4-(1,3,2)dithiarsolan-2-yl-phenyl)hexahydro-2-oxo-(3aS,4S,6aR)-1H-trieno(3,4-d)imidazole-4-pentamide
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p-aminophenylarsine oxide
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4-aminophenyldichloroarsine
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Mercaptoethanol
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Biotin
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1,2-ethanedithiol