Nutritional control via Tor signaling in Saccharomyces cerevisiae

Curr Opin Microbiol. 2008 Apr;11(2):153-60. doi: 10.1016/j.mib.2008.02.013. Epub 2008 Apr 8.

Abstract

The yeast Saccharomyces cerevisiae senses and responds to nutrients by adapting its growth rate and undergoing morphogenic transitions to ensure survival. The Tor pathway is a major integrator of nutrient-derived signals that in coordination with other signaling pathways orchestrates cell growth. Recent advances have identified novel Tor kinase substrates and established the protein trafficking membranous network and the nucleus as platforms for Tor signaling. These and other recent findings delineate distinct signaling branches emanating from membrane-associated Tor complexes to control cell growth.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Gene Expression Regulation, Fungal*
  • Protein-Serine-Threonine Kinases
  • Saccharomyces cerevisiae / enzymology
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / growth & development*
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism*
  • Signal Transduction*

Substances

  • Saccharomyces cerevisiae Proteins
  • Protein-Serine-Threonine Kinases
  • target of rapamycin protein, S cerevisiae