Factors influencing EPA+DHA levels in red blood cells in Japan

In Vivo. Jan-Feb 2008;22(1):131-5.


The blood eicosapentaenoic and docosahexaenoic acid (EPA+DHA) concentration is an important inverse risk factor for sudden cardiac death. However, it is not known what kinds of factors influence the EPA+DHA levels in the total phospholipid fraction in red blood cells (RBC EPA+DHA) in Japan, who regularly eat more fish with increasing age. Four hundred and fifty-six healthy individuals (320 men and 136 women, 18 to 70 years old) were recruited between 2002 and 2005. RBC EPA+DHA were measured by gas chromatography and questionnaires were administered. Multivariate analysis indicated that there were significant correlations between RBC EPA+DHA and (i) dietary EPA+DHA (beta=0.31), (ii) age (beta=0.33), (iii) gender (beta=-0.15) and (iv) physical activity (beta=-0.11) but not with body mass index or smoking.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Chromatography, Gas
  • Diet*
  • Docosahexaenoic Acids / analysis
  • Docosahexaenoic Acids / blood*
  • Eicosapentaenoic Acid / analysis
  • Eicosapentaenoic Acid / blood*
  • Erythrocytes / chemistry
  • Erythrocytes / metabolism*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Motor Activity
  • Multivariate Analysis
  • Sex Factors


  • Docosahexaenoic Acids
  • Eicosapentaenoic Acid