mRNA export: RNP remodeling by DEAD-box proteins

Curr Biol. 2008 Apr 8;18(7):R297-9. doi: 10.1016/j.cub.2008.02.027.

Abstract

The DEAD-box protein Dbp5 was thought to remodel ribonucleoproteins and displace proteins from these complexes in an ATP-dependent fashion to allow for mRNA export from the nucleus. A recent study on Dbp5 shows, however, that its ADP-bound form may also perform an important function in displacing export factors from mRNA.

MeSH terms

  • Adenosine Diphosphate / metabolism*
  • Cell Nucleus / metabolism*
  • DEAD-box RNA Helicases / metabolism*
  • RNA, Messenger / metabolism*
  • Ribonucleoproteins / metabolism*

Substances

  • RNA, Messenger
  • Ribonucleoproteins
  • Adenosine Diphosphate
  • DEAD-box RNA Helicases