Hematopoietic stem cells in transit--where's the niche?

Cell Stem Cell. 2008 Apr 10;2(4):302-4. doi: 10.1016/j.stem.2008.03.017.


In this issue of Cell Stem Cell, Min et al. (2008) identify Egr1 as a novel hematopoietic stem cell (HSC) transcription factor that regulates proliferation and mobilization of these cells. An improved understanding of Egr1 targets may lead to better strategies to expand populations of HSCs ex vivo for therapeutic applications.

Publication types

  • Comment
  • Editorial

MeSH terms

  • Animals
  • Cell Movement / physiology
  • Cell Proliferation
  • Early Growth Response Protein 1 / physiology
  • Hematopoietic Stem Cells / cytology*
  • Hematopoietic Stem Cells / physiology
  • Humans


  • EGR1 protein, human
  • Early Growth Response Protein 1
  • Egr1 protein, mouse