Cholinergic and GABAergic innervation regulate activity of electrogenic ionic pump in earthworm somatic muscle cells

Bull Exp Biol Med. 2007 Aug;144(2):163-5. doi: 10.1007/s10517-007-0279-4.

Abstract

Carbacholine reduced, while baclofen and norepinephrine increased resting membrane potential in earthworm somatic muscle cells. In the presence of carbacholine, neither norepinephrine, nor baclofen hyperpolarized the membrane. Ouabain decreased resting potential and abolished the effects of carbacholine, norepinephrine, and baclofen on membrane potential. It was hypothesized that carbacholine directly inhibited the ouabain-sensitive component of Na+/K+ pump and abolished the activating effect of norepinephrine and baclofen.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Atropine / pharmacology
  • Baclofen / pharmacology
  • Carbachol / pharmacology
  • Cholinergic Fibers / drug effects
  • Cholinergic Fibers / metabolism
  • Ion Pumps / metabolism*
  • Membrane Potentials / drug effects
  • Muscle Cells / drug effects
  • Muscle Cells / metabolism*
  • Norepinephrine / pharmacology
  • Oligochaeta / cytology
  • Oligochaeta / drug effects
  • Oligochaeta / metabolism*
  • Ouabain / pharmacology
  • Sodium-Potassium-Exchanging ATPase / metabolism
  • Tubocurarine / pharmacology
  • gamma-Aminobutyric Acid / metabolism

Substances

  • Ion Pumps
  • gamma-Aminobutyric Acid
  • Ouabain
  • Atropine
  • Carbachol
  • Sodium-Potassium-Exchanging ATPase
  • Baclofen
  • Tubocurarine
  • Norepinephrine